Long-term testosterone therapy can help men with hypogonadism lose weight and maintain their weight loss, researchers from Germany and the United States report. Ten-year results of the ongoing study will be presented Monday at ENDO 2019, the Endocrine Society’s annual meeting in New Orleans, La.
“Obesity is very common in men with testosterone deficiency (hypogonadism),” said lead study author Karim Haider, M.D., a urologist and andrologist in private practice in Bremerhaven, Germany. “Men with hypogonadism and obesity receiving long-term testosterone therapy achieved progressive and sustained weight loss, while untreated controls gained. The favorable decreases in weight and waist circumference may have contributed to the observed reductions in mortality and major cardiovascular events.”
Haider and his colleagues conducted a ten-year study in a urological office. Men on average were in late fifties to mid-sixties. Obese patients were given choice to be treated with long term testosterone therapy with testosterone undecanoate injections every 12 weeks and those that declined served as controls in the study.
Over 10 years, the testosterone-treated men lost 20.3 percent of their baseline weight (50.5 lb; 22.9 kg); their waist circumference dropped by 12.5 cm (4.9 in). BMI decreased by 7.3 kg/m2, and the waist-to-height ratio decreased by 0.07.
By contrast, the untreated men gained 3.9 percent of their baseline weight (3.2 kg; 7.1 lb), and their waist size increased by 4.6 cm (1.8 in). In this group, BMI increased by 0.9 kg/m2, and waist-to-height ratio increased by 0.03.
During this time, 12 (4.4 percent) men in the testosterone group died, while in the untreated control group, 57 deaths (30.2 percent), 47 myocardial infarctions (24.9 percent) and 44 strokes (23.3 percent) occurred.
“Our study found long-term testosterone therapy in men with hypogonadism and obesity resulted in significant improvement in measures of body size and composition,” Haider said. “In addition, testosterone therapy was associated with a reduced risk of death, heart attack and stroke. This suggests testosterone levels should be measured in men with obesity, and testosterone therapy should be offered if indicated.”
Dr. T’s Bottom Line:
I have been speaking about the risks of low testosterone in men for years. I highly recommend testing free testosterone levels in all of my patients.
If discovered to be low, one must follow the diet in The Hormone Boost or Supercharged Hormone Diet that helps natural production of testosterone: follow my sleep rules; and consider taking 3 Clear Libido on rising for three months – then retesting levels to ensure they have improved. If you are under stress or have broken sleep patterns, take 1 Clear Balance in the morning and 2 before bed to lower cortisol and raise DHEA, a precursor to testosterone.